Butylated hydroxyanisole (1986)
Abstract
The repeated oral administration of butylated hydroxyanisole (BHA) to rats and hamsters produced tumours of the forestomach, an organ not found in man. BHA has demonstrated little mutagenic activity and it is, therefore, probably carcinogenic in rats and hamsters via a non-genotoxic mechanism. On repeated oral exposure, it induced injury to the forestomach in rats and hamsters, liver effects in a range of species including monkeys, kidney damage in rats and rabbits, and thyroid injury in pigs. There was no convincing evidence of reproductive toxicity for orally-administered BHA in hamsters, pigs and monkeys. It is foetotoxic in rabbits and it may have effects on young rats and mice, exposed to the chemical prenatally. Allergic or intolerant reactions have been observed in a number of individuals after oral exposure to BHA. The chemical is a skin sensitizer and irritant in some individuals.
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