Acetophenone (1991)
Abstract
Acetophenone was a skin irritant in rabbits and guinea-pigs, and possibly also in man. It was a severe eye irritant in rabbits. No skin-sensitizing potential was demonstrated when solutions of acetophenone were tested on humans or guinea-pigs. Acetophenone had a moderate to low acute oral toxicity in laboratory animals and a low dermal toxicity in guinea-pigs. Central nervous system depression occurred in laboratory animals exposed orally and by injection and possibly also in volunteers treated orally. In a poorly reported study, repeated topical application to pregnant rats did not affect foetal development. There was no evidence of mutagenicity in Ames bacterial tests. Chromosome damage has been reported in hamster cells in culture.
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