Toxicity Profile for Butylparaben (1989)
Abstract
Butylparaben was a skin irritant in man. Experimental studies in volunteers failed to uncover any sensitizing potential, but sensitization to butylparaben has been demonstrated in dermatitis patients. A low acute oral toxicity was seen in mice treated with the ester whereas the sodium salt was of moderate toxicity. Injury to the forestomach of rats was produced by repeated dietary administration of the ester; in mice, there were effects on the spleen and thymus as well as liver damage. No convincing evidence of carcinogenicity was seen in a long-term feeding study in which mice received either the straight chain or branched ester. Neither isomer gave evidence of mutagenicity in Ames bacterial tests.
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