Toxicity Profile for Guanine (1998)
Abstract
Guanine is a natural constituent of the diet. It was evidently responsible for skin sensitization reactions seen in patients with nail polish contact allergy. A limited oral study in rats found no kidney damage. Obvious foetal malformations were not induced when pregnant hamsters were given a single intraperitoneal injection. Guanine produced chromosomal damage in human and mouse cells in culture, although possibly this was not due to a direct effect on the genetic material. No convincing evidence of chromosome damage was found in mice treated by intraperitoneal injection, and negative results were obtained in other genotoxic screening tests. Repeated subcutaneous injections were associated with mammary tumours in female rats, but the significance of this is unclear.
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