Butyl benzyl phthalate (1992)
Abstract
Butyl benzyl phthalate (BBP) has, in general, caused little skin irritation in humans, although Soviet investigators have reported more severe local effects in rodents, particularly after repeated applications. The neat liquid produced mild, transient eye irritation in rabbits. Early reports suggesting weak skin sensitizing activity in animals have not been confirmed in more recent human or animal studies. BBP was of low acute toxicity by the oral or dermal routes in laboratory animals. Rats given repeated oral or inhalation exposures showed internal bleeding in some studies, effects on the liver, kidneys, pancreas and nervous system, and degeneration of the thymus and spleen and of the male reproductive organs. Multiple skin applications caused nervous system toxicity in mice. The reproductive capacity of male rats was totally suppressed at high oral doses, whilst oral administration to pregnant rats, mice and rabbits caused foetotoxic effects (mainly) at maternally toxic dose levels. In mice there was an increase in foetal malformations at maternally toxic dose levels. In long-term feeding studies, an increased incidence of leukaemia was seen in female rats, but there was no evidence of carcinogenicity in mice. Negative results have been obtained in a range of genotoxicity assays including a mouse injection study, tests on mammalian cells in culture and Ames bacterial tests for mutagenicity.
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