Toxicity Profile for N-Methylol acrylamide (1990)
Abstract
N-Methylol acrylamide was a mild skin and eye irritant in the rabbit. Skin sensitization has been demonstrated in man. Administration of single doses to laboratory animals indicated a moderate oral and low dermal toxicity. Repeated oral administration has produced neurotoxicity in mice and rats, with degeneration of the ovaries in female mice and testes damage leading to reduced fertility in male mice. N-Methylol acrylamide given orally was carcinogenic to mice, inducting tumours of the liver, lungs, harderian glands [accessory tear glands] and ovaries. It was not mutagenic in the bacterium Salmonella typhimurium (Ames test) but produced sperm abnormalities on oral administration to mice.
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