In man, propylene in the gaseous state is not irritating to the skin, although in liquified form it can cause skin and eye burns. The gas is possibly an irritant to the eyes and mucous membranes. Inhalation rapidly induces anaesthesia and other effects on the central nervous system.
In long-term inhalation studies there was nasal inflammation in rats and mild kidney injury in mice; shorter-term exposure resulted in liver effects in rodents. There was no convincing evidence of carcinogenicity in rats or mice exposed to propylene in the atmosphere. DNA binding has been detected in mice exposed to propylene in the atmosphere. Inconclusive results have been obtained in mutagenicity assays.
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