Toxicity Profile for Propylene glycol alginate (1989)
Abstract
Injection of propylene glycol alginate (PGA) beneath the skin of humans produced skin irritation and sensitization. PGA was of low acute oral toxicity in various species of laboratory animals and repeated oral administration failed to identify any particular target organ. There was no evidence of reproductive toxicity in feeding studies in a range of species, although maternal and early foetal deaths occurred in mice. Limited long-term oral studies in rats and mice gave no indication of carcinogenicity. A broad range of genotoxicity screening assays produced no convincing evidence of activity.
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