Toxicity Profile for 2-Bromo-2-nitro-1,3-propanediol (1995)

Abstract

2-Bromo-2-nitro-1,3-propanediol (BNP) was a skin and eye irritant in man and laboratory animals. It has demonstrated skin sensitization potential in humans and guinea-pigs. The acute oral toxicity to rats, mice and dogs was moderate with toxic effects including gastro-intestinal damage. In rats, single exposure was moderately toxic by the dermal route. Effects seen on repeated oral administration to rats included changes to the gastro-intestinal tract, kidneys, gastric lymph nodes and salivary glands. A decrease in maternal weight gain has been reported in pregnant rats and rabbits fed BNP but there were no effects on the foetuses apart from delayed skeletal development in rats. A limited report noted no evidence of carcinogenicity in rats treated orally or in mice treated dermally. BNP gave no indication of mutagenicity in mice or in Ames bacterial tests.