1,3-Dichloro-2-propanol (2005)
Abstract
l,3-Dichloro-2-propanol (1,3-DCP) induced tumours in the liver, kidneys, tongue and thyroid when administered in the drinking water of rats. It failed to produce chromosome or DNA damage in rats treated by stomach tube, but was active in a range of other genotoxicity screening assays including tests for chromosome effects in mammalian cells in culture and (Ames) tests for mutagenicity in bacteria. Repeated administration to rats either in the drinking water or by stomach tube caused effects on the liver, kidneys, stomach and nasal tissues, and various changes in the blood including a reduction in the number of red blood cells and platelets (needed for blood clotting). In limited studies involving single subcutaneous injection or repeated stomach tube administration, there was some evidence of possible effects on the male rat reproductive system. A high to moderate acute toxicity has been recorded in laboratory animals treated orally, dermally or by inhalation. In rabbits, 1,3-DCP caused severe eye injury and effects on the skin. Liver damage and deaths have occurred in workers following an ill-defined acute exposure.
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