Toxicity Profile for Methyl isobutyl carbinol (1994)
Abstract
Methyl isobutyl carbinol was an eye and respiratory irritant in man and laboratory animals, and a skin irritant in rabbits. It was of low to moderate acute toxicity by the oral, dermal and inhalation routes in various species of laboratory animals. Mice exposed to the vapour showed damage to the lung, liver and kidney, repeated inhalation caused kidney damage in rats, and anaesthesia occurred in rodents after inhalation or oral exposure. No mutagenic activity was seen in bacterial tests (including the Ames assay), yeast, or mammalian cells tested in culture.
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