Toxicity Profile for para-Isopropyltoluene (1991)
Abstract
para-Isopropyltoluene was irritant to the skin of rabbits, rats and guinea-pigs and caused local irritation in rats exposed by inhalation. No skin sensitization was induced in volunteers treated with dilute solutions. Repeated oral administration to humans caused nausea, headache and vomiting. Low acute toxicity was demonstrated in rodents treated orally and in rabbits treated dermally. Effects on the central nervous system and blood were found in laboratory animals treated by the oral, dermal and inhalation routes. An unspecified isomer of isopropyltoluene gave no evidence of mutagenicity in assays using bacteria (including the Ames test) or yeast.
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