Toxicity Profile for N,N'-Diphenyl-para-phenylenediamine (1989)
Abstract
N,N’-Diphenyl-para-phenylenediamine (DPPD) has caused skin sensitization reactions in several subjects and evidently was mildly irritant to rabbit eyes. Acute oral and dermal toxicities were low in rodents. Dietary administration to rats caused a reduction in liver weight and changes in the kidneys and blood, whilst in reproductive studies it reduced litter sizes and interfered with the normal birth process, causing fatalities in both mothers and pups. Long-term feeding studies in rodents gave no evidence of carcinogenicity, but DPPD induced mutations in mammalian cells in culture and in an Ames bacterial test.
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