Allyl alcohol (1995)
Abstract
Allyl alcohol is a skin, eye and mucous membrane irritant in man and evidently can be absorbed through the skin. In acute studies in laboratory animals, it demonstrated a moderate to high toxicity irrespective of route, the main sites of action being the liver, kidney, lung and central nervous system. In repeated oral studies in rats, allyl alcohol produced principally kidney and liver injury. Multiple inhalation exposures caused liver, lung and kidney damage in a range of laboratory animals. Allyl alcohol was mutagenic in the Ames bacterial test and in mammalian cells in culture. There was no evidence of mutation in male rats treated orally. Limited oral studies in rats and hamsters generated no evidence of carcinogenic potential.
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