Calcium sulphate (1989)
Abstract
The anhydrous and hemihydrate forms of calcium sulphate have displayed a weak irritant potential to the skin of humans. However, Plaster of Paris casts, containing mainly the hemihydrate, have been generally well tolerated and have displayed little sensitizing potential. A hemihydrate paste was not irritant to the eyes of rabbits. Occupational exposure to the dihydrate has occasionally been associated with a decrease in lung function. Limited studies involving the repeated inhalation of an [unspecified] calcium sulphate failed to identify any particular target organs in monkeys, rats and hamsters. No evidence of mutagenicity was found in Ames bacterial tests. The sulphate ion has caused gastro-intestinal disturbance in humans following large oral doses.
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