alpha-Methylstyrene (1989)
Abstract
alpha-Methylstyrene was a skin and eye irritant in rabbits and when present in the atmosphere induced eye and nasal irritation in humans. It is possibly a skin sensitizer. A low acute oral and inhalation toxicity was demonstrated in laboratory animals. The sites of toxic injury in the oral studies included the nervous system, liver, lung, kidney, and gastro-intestinal tract. Studies conducted in the West involving repeated inhalation found mild effects on the liver and kidney in several species of laboratory animal, whereas a much wider range of toxicity targets and more severe damage were reported in Soviet studies of rats exposed to alpha-methylstyrene and in Soviet workforces exposed principally to alpha-methylstyrene and butadiene. Reproductive effects occurred in rats exposed to alpha-methylstyrene by inhalation. Chromosomal effects in human cells in culture have been claimed.
Toxicity Profiles are comprehensive, yet concise, monographs on the hazard potential of individual chemicals. They are written by scientists specially trained in the evaluation of toxicity data and are prepared principally from primary information sources. To see the full list of nearly 500 Toxicity Profiles currently available, please click here. Profiles can be obtained by contacting our help desk (e-mail document@bibratoxadvice.co.uk) or by completing the enquiry form on the Contact Us page.
Copyright © 1989 BIBRA Information Services Ltd