Toxicity Profile for 1,3-Butylene glycol (1990)
Abstract
1,3-Butylene glycol has caused some skin irritation in man and laboratory animals. Eye irritation occurred in one individual, although its irritant potency in rabbits appeared lower. It was of low acute oral toxicity to rodents. Feeding studies in which 1,3-butylene glycol replaced carbohydrate as an energy source found central nervous system effects in rats, dogs and calves. 1,3-Butylene glycol was foetotoxic when fed to rats during pregnancy, and a multigeneration feeding study in rats gave some indications of reduced male fertility. No genotoxic activity (dominant lethality or chromosomal damage) was seen in rats treated orally.
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