Thiophene (1989)
Abstract
In man, thiophene has caused skin irritation and may induce sensitization responses. Nausea, itching and jaundice were seen in a woman repeatedly taking thiophene in suppositories. It was of moderate to low acute oral toxicity in mice and rats, and of moderate toxicity by inhalation to mice. Repeated oral exposure to rats caused effects on the liver, kidney and heart. In rats, mice and rabbits, effects on the thyroid, liver, lung, heart and adrenals were seen following repeated inhalation. Cellular effects in the brain of rats have been reported after repeated subcutaneous injections. Thiophene was not mutagenic in Ames bacterial tests.
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