Toxicity Profile for Polypropylene glycol (1990)
Abstract
Polypropylene glycols (PPGs) were not irritant to human skin. In rabbits, they caused slight skin effects and eye irritation. Acute oral toxicities in laboratory animals ranged from low (for PPGs of molecular weight 2000 or more) to moderate (generally for shorter chain materials). Central nervous system (CNS) disturbances and tissue abnormalities in the liver, kidneys, lungs and spleen were among the recorded effects. Acute dermal toxicity was low in rabbits. Single injections caused effects on the CNS. Polypropylene glycol of undefined specification was mutagenic in an Ames bacterial test.
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