Toxicity Profile for Phenylacetic acid and its sodium salt (1989)
Abstract
The acid did not induce skin sensitization in volunteers. Vomiting, nausea and lethargy were reported in patients (with urea cycle disorders) treated orally or intravenously with a formulation containing sodium phenylacetate. Phenylacetic acid was of low acute toxicity in rodents treated orally and in rabbits treated dermally. Dogs given repeated oral doses of the sodium salt suffered kidney damage and central nervous system effects. Oral administration of phenylacetic acid to pregnant rats resulted in foetotoxicity. Subcutaneous injections of phenylacetic acid or sodium phenylacetate apparently impaired brain development in young rats.
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