Formamide (1990)
Abstract
Formamide caused skin irritation in rats and guinea-pigs and was an eye irritant in rabbits. It was of low acute toxicity by the oral and dermal routes in rodents. Repeated oral administration to rats caused tissue changes at a number of sites including the gastro-intestinal tract, spleen, testes and blood. Multiple dermal or inhalation exposures induced blood effects, changes in organ weights and testes damage in rats. Foetal malformations and foetotoxicity were induced when laboratory animals were treated by the oral, dermal and injection routes during pregnancy. Chromosome damage was reported in rats treated with formamide but no evidence of mutagenicity was seen in Ames bacterial tests.
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