Diethylamine and its hydrochloride (1997)
Abstract
Diethylamine was severely irritant to the skin, eyes and respiratory passages of humans and various species of laboratory animals and has been reported to cause skin sensitization in humans. It was of moderate acute toxicity to laboratory animals when administered orally, dermally or by inhalation. The liver and kidneys have been identified as the main target organs in rabbits given repeated inhalation and oral exposures. No evidence of mutagenicity was seen in Ames bacterial assays. DNA damage did not occur in rats treated orally. In studies of nitrosamine formation, the combined oral administration of diethylamine hydrochloride and sodium nitrite resulted in an increased incidence of liver tumours in mice.
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