Didodecyl thiodipropionate (1989)
Abstract
Didodecyl thiodipropionate gave some indication of irritancy to human skin on repeated application and was an irritant to rabbit eyes. No evidence of local sensitization was reported on repeated application to human or guinea-pig skin. It was of low acute toxicity by the oral route to rats and mice and limited studies involving repeated oral administration to rats and dogs failed to identify target organs for toxic attack. No adverse reproductive effects were seen in rabbits, hamsters, mice and rats treated orally during pregnancy and, in limited feeding studies, no evidence of carcinogenicity was reported in rats. It did not cause chromosomal damage in rats or mice and was negative in a dominant lethal test in rats. Some indication of mutagenicity was seen in bacteria.
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