Monoisopropanolamine (1999)
Abstract
A single case of eye irritation and a few cases of dermatitis have been recorded in humans occupationally exposed to monoisopropanolamine. No skin sensitization was induced in volunteers treated with dilute solutions. Monoisopropanolamine caused severe skin and eye irritation in rabbits, whilst nasal and lung irritation were observed in mice exposed to an aerosol. In laboratory animals, the acute toxicity of monoisopropanolamine was generally low when given orally, and moderate when applied dermally. A limited [oral?] study gave some indication of a foetotoxic effect in rats. There was no convincing evidence of mutagenicity in bacterial assays (including Ames tests).
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