Toxicity Profile for Angelica (1993)
Abstract
Angelica seed oil has produced mild skin irritation in rabbits. Phototoxic reactions occurred in humans and laboratory animals treated dermally with various angelica extracts. Skin sensitization reactions have been reported in two dermatitis patients tested with angelica root oil whilst ingestion of a root extract produced a widespread rash in another individual. Both the seed oil and root oil were of low acute oral and dermal toxicity in rodents and rabbits. Short-term oral administration of various angelica root extracts has produced effects in the lung and spleen, and damage to the liver and kidney of rodents. In bacterial tests using root extracts, there was evidence of mutagenic activity (in the Ames assay) and of DNA damage.
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