Toxicity Profile for Cinnamyl anthranilate (1994)

Abstract

Cinnamyl anthranilate caused slight skin irritation in rabbits; a dilute solution did not produce skin irritation or skin sensitization in volunteers. It was readily absorbed through intact rat and monkey skin, and through the excised skin of humans. The acute toxicity was low in rats treated orally and in rabbits treated dermally. Changes in liver ultrastructure (including peroxisomal proliferation) and function were evident after its short-term oral or intraperitoneal administration to rats and mice, whilst in long-term feeding studies rats showed an increase in kidney damage in both sexes and iron deposition in the spleen of females. A low incidence of rare kidney and pancreatic tumours was found in high-dose male rats, while in mice there was an increase in liver tumours. Cinnamyl anthranilate also increased lung tumours on intraperitoneal injection into a susceptible mouse strain. There was no conclusive evidence of chromosomal or DNA damage in rodents treated orally or by intraperitoneal injection, but some activity was recorded in genotoxicity screening tests in mammalian cells in culture (mutagenicity and transformation). Cinnamyl anthranilate was not mutagenic in fruit flies and in Ames bacterial tests but did induce mutations in other bacterial assays.