2,6-Dinitrotoluene (1994)
Abstract
2,6-Dinitrotoluene (2,6-DNT) induced liver cancer in rats treated orally. Chromosomal damage, DNA damage and DNA binding have been detected in rats given 2,6-DNT by the oral and intraperitoneal routes, and mutagenicity was recorded in Ames bacterial tests. Repeated oral administration produced effects on the testes in rats, mice and dogs, liver damage and effects on the blood in rats and dogs, and kidney damage and neurotoxic effects in dogs. 2,6-DNT was of moderate acute oral toxicity in rodents, and exhibited a low degree of skin and eye irritancy in rabbits. Guinea-pig studies suggested a weak skin sensitizing potential.
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