Hafnium dioxide had a low acute oral toxicity in mice. When given repeatedly to guinea pigs by stomach tube, slight tissue changes were seen in the lungs and liver. Lung changes were also seen following a single instillation into the windpipe of rats.
Hafnium carbide had a low acute oral toxicity in mice but produced lung changes in rats when instilled into the windpipe on a single occasion.
A single instillation of hafnium dihydride into the windpipe of rats induced biochemical changes in the heart and brain, possible evidence of liver dysfunction, and tissue changes in the heart, liver, lungs, kidneys and spleen.
Cell proliferation and benign local tumours resulted in mice given a single intradermal injection of hafnium oxychloride.
Hafnocene dichloride induced DNA adducts when incubated with mammalian DNA.
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