Mandelic acid and its common salts (1995)
Abstract
Mandelic acid has caused skin sensitization in one individual. The acid and its simple salts were of fairly low acute oral toxicity in rats, rabbits and guinea-pigs. Liver and kidney abnormalities, stomach damage and convulsions occurred in laboratory animals treated orally with these materials. Injections of the acid and its salts caused various effects including liver and kidney abnormalities and biochemical changes in the brain in various species of laboratory animal. Transient effects have been reported following repeated oral administration of mandelic acid and its salts to patients with urinary bacterial infections. The reproductive toxicity of mandelic acid has not been adequately tested. No genotoxic activity was demonstrated in a range of screening assays using the benzyl ester.
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