Fumaric acid and its common salts (1991)
Abstract
Fumaric acid is a normal body metabolite in man. The acid and its common salts were of low acute oral and dermal toxicity in rats and rabbits. Testes degeneration was evidently induced in rats given repeated oral doses of the acid. Intraperitoneal injection produced liver damage in rats treated with fumaric acid, and thyroid and pituitary effects, testes damage and hormonal changes in rabbits treated with sodium fumarate. In limited feeding studies, the acid had no reproductive effects in the guinea-pig and gave no evidence of carcinogenicity in rats. Fumaric acid was not mutagenic in Ames bacterial tests, and did not induce chromosomal damage in mammalian cells in culture. The acid severely irritated the eyes of rabbits and has been described as mildly irritant to human skin.
Toxicity Profiles are comprehensive, yet concise, monographs on the hazard potential of individual chemicals. They are written by scientists specially trained in the evaluation of toxicity data and are prepared principally from primary information sources. To see the full list of nearly 500 Toxicity Profiles currently available, please click here. Profiles can be obtained by contacting our help desk (e-mail document@bibratoxadvice.co.uk) or by completing the enquiry form on the Contact Us page.
Copyright © 1991 BIBRA Information Services Ltd