Toxicity Profile for 2-Hydroxy-3-naphthoic acid (1999)
Abstract
2-Hydroxy-3-naphthoic acid (HNA) irritated the eyes of rabbits, and was a skin irritant in some species of laboratory animal. It may have caused skin disease and upper respiratory tract effects in workers. HNA was of moderate acute oral toxicity in various species of laboratory animals. Studies involving repeated administration by the oral and inhalation routes gave indications of an effect on the kidneys, and possibly adrenals, of rats. Chromosomal damage was not induced in the bone marrow cells of hamsters treated orally, but was reported in hamster lung cells treated in culture. HNA was judged to be non-mutagenic in Ames bacterial tests and was also negative in other bacterial mutagenicity assays.
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