Toxicity Profile for Dodecyl benzene sulphonate (1990)

Abstract

Dodecyl benzene sulphonate irritated the skin of man and the eyes of rabbits but dilute solutions showed no local sensitizing potential in guinea-pigs. It was of moderate acute oral toxicity in laboratory animals. Effects on the liver and caecum occurred in rats and dogs given repeated oral doses. There was no evidence of foetotoxicity or teratogenicity in rats given oral or dermal doses throughout pregnancy. Limited long-term tests revealed no evidence of carcinogenic potential in rats treated orally or in mice and rabbits treated dermally. There was no evidence of chromosomal damage in rodents treated orally or by injection. No genotoxicity was induced in mammalian cells in culture and no mutagenicity was seen in Ames bacterial tests.