Triethylene glycol diacetate (2001)
Abstract
Triethylene glycol diacetate was mildly irritant to the skin of guinea-pigs, and to the skin and eyes of rabbits. It was apparently not a skin sensitizer in guinea-pigs. In laboratory animals, acute toxicity by the oral, dermal, and the inhalation routes was low. Liver damage occurred in short-term feeding studies in rodents given high dose levels. There was no indication of any marked reproductive or developmental toxic potential in mice treated orally. Brief citations noted evidence of mutagenicity to bacteria (in an Ames test) and chromosomal changes in mammalian cells in culture. Triethylene glycol diacetate has not been tested in long-term studies for carcinogenicity.
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