Toxicity Profile for Malic acid and its common salts (1992)
Abstract
L-Malic acid occurs naturally in the diet and is a normal body metabolite. The DL-form is of low oral toxicity in laboratory animals after both acute and repeated exposures. DL-Malic acid gave no evidence of reproductive effects in rodents treated orally. No signs of genotoxic activity were reported for DL-malic acid and its sodium salt in a limited range of screening tests, including Ames bacterial tests. Malic acid was irritant to the skin and eyes of laboratory animals.
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