Toxicity Profile for Sorbitan trioleate (1994)
Abstract
Sorbitan trioleate was only mildly irritating to the skin and eyes of rabbits and was of low acute oral toxicity in rats. Human volunteer studies suggested a low skin sensitizing and irritant potential. A single benign skin tumour that was possibly treatment-induced was seen in a 52-wk mouse skin painting study involving daily application of sorbitan trioleate. In rats, repeated injections produced effects on the blood and spleen. A range of other sorbitan fatty acid esters have demonstrated a low toxicity in repeated oral studies in rats.
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