Sorbitan trioleate (1994)
Abstract
Sorbitan trioleate was only mildly irritating to the skin and eyes of rabbits and was of low acute oral toxicity in rats. Human volunteer studies suggested a low skin sensitizing and irritant potential. A single benign skin tumour that was possibly treatment-induced was seen in a 52-wk mouse skin painting study involving daily application of sorbitan trioleate. In rats, repeated injections produced effects on the blood and spleen. A range of other sorbitan fatty acid esters have demonstrated a low toxicity in repeated oral studies in rats.
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