Repeated oral administration of allyl isovalerate to rats and mice principally caused liver damage, and cancers of the blood cell forming system. Effects were also seen on the gastro-intestinal tract, bladder, lymph nodes, adrenals, spleen, kidneys and bone marrow.
Mutagenicity tests in bacteria (Ames assay) and fruit flies gave negative results, however, in mammalian cells in culture, chromosomal damage and mutations were induced.
Allyl isovalerate was of moderate acute oral and dermal toxicity in laboratory animals. Undiluted, it was moderately irritant to rabbit skin, but a dilute solution produced no irritation in man. An attempt to induce sensitization in volunteers using a dilute solution was unsuccessful.
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