Toxicology and Regulatory News - CONTENTS Archive

Volume 46, Number 2

February 2007 

PART I: WORLD NEWS

INTERNATIONAL

IARC verdicts on lead, formaldehyde, 2-butoxyethanol and 1-tert-butoxypropan-2-ol
SIDS Initial Assessment Reports (SIARs) – draft assessments on many chemicals
JECFA veterinary residues
Environmental Health Criteria on dermal absorption

EUROPEAN UNION

Formal adoption of REACH
EU risk assessment report on 3,4-dichloroaniline and an amendment on phenol
Recent SCHER deliberations …
… on sodium hydroxide
… and tributyl tin, dibutyl tin, dioctyl tin and triphenyl tin
ECETOC publications on trifluoroethane and synthetic amorphous silica …
…. and on OELs for data-poor substances
CoE reviews potentially harmful phytochemicals in cosmetics
Draft evaluations (and one final evaluation) on biocides available from EC
Animal feed contamination by DDT assessed by EFSA
EC Community Register of Feed Additives
EFSA food-contact assessments
EFSA approves cassia gum as a food additive
Dietary fibre reviewed by ILSI Europe
Genetically modified (GM) sugar beet and cotton seed assessed by EFSA
ECVAM verdicts on an in vitro genotoxicity test, a corrosivity test, and toxicity testing in dogs

UNITED STATES

NTP carcinogenicity studies on divinylbenzene and mixtures of dioxin-like compounds
CERHR considers reproductive and developmental toxicity of bisphenol A and DEHP
EPA IRIS summaries and supporting toxicological reviews
HPV submissions on 4-vinylcyclohexene and tris(hydroxymethyl)aminomethane
Cosmetic Ingredient Review Expert Panel announcements
CIR final reports on triethylene glycol, PEG-4 and specific rice-derived ingredients
Public Health Goals – OEHHA pronouncements
Pesticide tolerance petitions filed with the EPA
EPA pesticide tolerances
EPA Reregistration Eligibility Decisions
FDA GRAS status letters
FDA propose food labelling health claim for calcium, vitamin D and osteoporosis

OTHER AUTHORITATIVE BODIES

Health Canada progress on prioritizing chemical risk assessments
NICNAS upgrades the cancer status of formaldehyde
DECOS recommends occupational exposure limit for tetrachloroethane …
… and considers diethylene glycol and propylene glycol


PART II: SHORT CUTS

 Carcinogenicity of 1,2-dichloroethane in rats and mice following inhalation exposure
Nonylphenol and 4-octylphenol affect liver in multi-generation rat study
Effects of DEHP on the reproductive health of female rat offspring
Bisphenol A and foetal mammary gland development
Carbon black and lung cancer – outlook not quite so dark?
Cancer risks from arsenic, cadmium, nickel, selenium and zinc
Cadmium may be toxic at levels previously accepted as “safe”
ortho-Phthalaldehyde implicated in asthma and contact dermatitis in a health worker
Genotoxicity of endosulfan and its metabolites
Prenatal exposure to chlorpyrifos may affect children’s neurodevelopment
1-Phenylethanol tested for genotoxicity in mice
Sodium fluoride produced no DNA damage in a comet assay in rats
Milk peptide may reduce high blood pressure
D-ribose gives reassuring results in 90-day rat feeding study
Curcumin tested for reproductive and developmental toxicity
Carrageenan with low MW component tested in 90-day rat feeding study
Reassuring findings for resveratrol in a mouse carcinogenicity study
Selenium status in the elderly – food for thought
High-selenium yeast tested for subchronic toxicity and genotoxicity
Vitamin D and multiple sclerosis
Childhood allergies and vitamins A and D
Folic acid and cardiovascular disease
The effect of kava extract on rat liver enzymes
Licorice extract rather than healthy eating for weight control?
Black tea consumption – is it a healthy habit?
Adding milk may reduce tea’s beneficial effects on the vascular system
Alcoholic drinks and stomach cancer
Nutty protection
Processed meat and prostate cancer