PART I: WORLD NEWSINTERNATIONALIARC verdicts on aromatic amines, organic dyes and related exposures Revised OECD Test Guidelines on repeated dose inhalation toxicity Report of the 68th JECFA meeting EUROPEAN UNIONREACH up a gear for pre-registration … download the IUCLID 5 pre-registration plug-in … and settle down to some more bedtime reading SCHER evaluates risk assessment reports Biocide evaluations available from EC Environment EFSA assesses the safety of mercury in animal feeds Provisional EC list of additives for food-contact plastics List of European and national legislation on food-contact materials Savouring flavourings – more EFSA evaluations Colourful EFSA assessment for lycopene in food EFSA statement on 3-monochloropropane-1,2-diol (3-MCPD) esters ECETOC report on the extended one-generation reproductive toxicity study UNITED KINGDOMCOC discusses 1,3-butadiene and Non-Hodgkin’s lymphoma (NHL) Terephthalic acid – COT draft update statement COT review of organophosphorus compounds HSE report on pesticide-related illness Chlorinated drinking water and cancer – COC waiting for the last drop! Water chlorination and adverse pregnancy outcome – draft COT statement COC discusses mixed up carcinogens COT looks at air fresheners Bracken considered by COT Pyrrolizidine alkaloids (PAs) in food – second draft COT statement FSA Board considers study on food additives and hyperactivity in children COT discusses FSA-funded studies on food additive mixtures and caffeine ACNFP April deliberations COC considers OECD Guidance Document for carcinogenicity studies … as well as IPCS mode of action (MOA) and human relevance All change at the HSE UNITED STATESMore NTP nominations Company submissions to the EPA HPV Program and EPA’s commitments under ChAMP No significant risk level (NSRL) set by OEHHA for C.I. Direct Blue 218 and ethylbenzene National Ambient Air Quality Standards (NAAQS) for ozone issued by EPA Pesticide tolerance petitions filed with the EPA EPA pesticide tolerances and health risk assessments Risk assessments issued by EPA as part of its pesticide reregistration programme EPA Registration Reviews for eight pesticide ingredients FDA GRAS status for krill-derived lecithin OTHER AUTHORITATIVE BODIESNICNAS – Full Public Reports on new chemicals DECOS reviews on the carcinogenicity and genotoxicity of various chemicals Skin penetration data for substances on the Swedish OEL list RIVM evaluates strategies for reproductive toxicity testing PART II: SHORT CUTSTesting time for 8-2 fluorotelomer alcohol in rat study Multi-wall carbon nanotubes (MWCNTs) show genotoxic potential in rats Chlorpyrifos and male reproductive health Endocrine disruptors reviewed Severe allergic response to salicylamide Di-2-ethylhexyl terephthalate not carcinogenic in rat study Reproductive toxicity of tetrahydrofurfuryl alcohol (THFA) in rats Butter flavouring and lung disease – cases may spread beyond popcorn workers Rat feeding study suggests no elegies for ellagic acid Safety assessment of modified gum acacia Weighing up safety of whey growth factor extract Lung cancer risk and vitamin supplements White tea and colon cancer Three generations of rats raised on genetically modified (GM) corn |