PART I: WORLD NEWSINTERNATIONALOECD Screening Information Data Sets (SIDS) and SIDS Initial Assessment Reports (SIARs) CICAD on heptachlor WHO reviews risks of N-nitrosodimethylamine (NDMA) in drinking water OECD review of (Q)SAR models Support for updating OECD test guideline 407 to detect endocrine modulators EUROPEAN UNIONAre you within REACH? EC draft proposal for a GHS Regulation ECETOC report on the safety of nanomaterials EC report on detergents and their ingredients EFSA assesses carbofuran Commission guidance on biocide submissions EC Community Register of Feed Additives Noni juice gets the nod from EFSA UNITED KINGDOMEffects of chemicals on the male reproductive system discussed by COT COT asked by MHRA to consider the toxicity of nanoparticles Health effects of common air pollutants considered in Defra document COT comment sought on WHO re-evaluation of TEFs for dioxin and dioxin-like compounds ACNFP considers several novel food ingredients UNITED STATESEPA IRIS external peer review summary of dibutyl phthalate health assessment Revised OEHHA list of Proposition 65 safe harbor levels OEHHA reconsiders vinclozolin as a known carcinogen CIR safety assessments and re-reviews Pesticide petitions filed with the EPA EPA pesticide tolerances EPA pesticide risk assessments FDA guidance for estimating dietary intake values NCEA application of PBPK models OTHER AUTHORITATIVE BODIESBfR investigate whether humans have the capacity to convert styrene to styrene oxide Danish EPA risk assessments IRSST review of health effects of nanoparticles FSANZ safety assessments PART II: SHORT CUTSortho-Chloronitrobenzene causes liver and kidney tumours in rodents Trichloroethylene – human risk assessment Multiple exposure routes – chloroform shows synergistic toxicity Latex allergy and health care workers Pesticides and Parkinson’s disease link strengthened Herbicide safety assessment Locust wood dust causes occupational asthma Occupational asthma linked to dried safflower and yarrow flowers Inhaled DEHP and female reproductive function Monocyclic aromatic amines form DNA adducts in mice In vitro genotoxicity of para-phenylenediamine but not its metabolites Passive smoking issues... miscarriage … death in non-smokers … and exacerbation of allergic responses Californians at carcinogenic risk from hexavalent chromium in drinking water? Deoxynivalenol damages human DNA at biologically relevant concentrations Ponceau 4R affects learning ability in young male mice Bamboo leaf extract showed no developmental toxicity in a rat study Typical phosphorus intakes may adversely affect bone health Copper, fat and cognitive function Iron and sugar may contribute to heart disease risk Coffee may increase immediate likelihood of a heart attack Apple allergens associated with different clinical symptoms? Noni juice and liver damage Remember to drink the juice! Grape seed extract and possible kidney toxicity Grape seed oligomers protect against bromate toxicity in rats The hunt for causes of oesophageal cancer – pick a food, any food Fruit and oral premalignant lesions Intake of certain foods can modify risk of recurring skin cancer PhIP-DNA adducts in the human pancreas may be related to pancreatic cancer Genotoxic carcinogens – risk assessment approaches Muta™Mouse can discriminate between carcinogens and non-carcinogenic analogues The value of in vitro genotoxicity tests for predicting mammalian carcinogenicity Physiological effects of drug solvents in rats
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