A report from the Dutch National Institute for Public Health and the Environment (RIVM) lists important categories of contact allergens in consumer products, discusses the prevalence of skin and other allergies in the Netherlands and in Europe, and provides insights into consumer exposure from a wide range of products (cosmetics, toys, cleaning materials, textiles etc.). It goes on to discuss the prediction of sensitizing potency, summarising (in Appendix 6) the potency estimates for numerous allergens present in different types of consumer product (based mainly on data from the local lymph node assay (LLNA) in mice). Data from the LLNA can also be used to predict the sensitization threshold of a chemical, and estimated thresholds in mice and humans are presented (in Table 15) for a number of common allergens. The report writers note that it is not currently possible to predict thresholds for elicitation. A short chapter on risk assessment for sensitizers discusses two quantitative methods that are presently under development, although neither is yet ready to be used in daily practice. One focuses on dose-response curves and potency information, while the other is based on the threshold of toxicological concern concept (where human exposure is low and sensitization data are not available). An example of a quantitative risk assessment is also provided (in Appendix 7).

[Wijnhoven S.W.P. et al. (2008). Allergens in consumer products. RIVM Report 320025001/2008. Available at http://www.rivm.nl/bibliotheek/rapporten/320025001.pdf on the internet.] {179251}

The above item is taken from the November 2008 issue of Toxicology and Regulatory News which is sent automatically to members of bibra (click here for more details).

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