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Developmental neurotoxicity (DNT) testing – is industry doing enough?

Developmental neurotoxicity (DNT) testing – is industry doing enough?

Neurodevelopmental disorders in children have increased significantly in recent years (according to the European Joint Research Centre), which adds urgency to the need to evaluate new and existing chemicals for their potential activity in this area. This is difficult when the existing OECD DNT study,…

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Public Health England reviews the evidence on e-cigarettes and heated tobacco

Public Health England reviews the evidence on e-cigarettes and heated tobacco

The effects of vaping on public health remains a newsworthy and interesting topic of discussion, with a range of views and opinions. Public Health England (PHE) is committed to reviewing the evidence regarding e-cigarette use and the effects of vaping on consumer health. PHE has…

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EFSA/ECHA guidance on identifying endocrine disruptors (EDs)

EFSA/ECHA guidance on identifying endocrine disruptors (EDs)

Hormonal disruption is a hot topic these days. Following 2016 draft EU legislation setting scientific criteria for identifying EDs (under plant protection and biocidal products Regulations), EFSA and ECHA have issued a draft guidance document on this subject. It includes advice on how to gather,…

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End of the line for the in vivo unscheduled DNA synthesis (UDS) assay?

End of the line for the in vivo unscheduled DNA synthesis (UDS) assay?

Establishing whether or not a substance is genotoxic is critical in risk assessment, as it determines whether the substance can be assessed as a threshold or non-threshold toxin. The OECD Test Guidelines (TGs) on genetic toxicology are considered the “gold standard” on how the favoured…

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QRA 2: The SCCS puts skin sensitisation risk assessment to the test

QRA 2: The SCCS puts skin sensitisation risk assessment to the test

Feeling a bit itchy? Skin sensitisation from fragrance ingredients in cosmetics, personal care products and household goods is relatively common and causes considerable concern for fragrance manufacturers and regulators. The QRA2 model, developed by the International Fragrance Association as part of the International Dialogue for…

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