Official enthusiasm for the Threshold of Toxicological Concept (TTC) is maintained. That is the tenor of the latest EFSA draft guidance document on this important topic (http://www.efsa.europa.eu/sites/default/files/consultation/consultation/181112-d.pdf). If you have any comments to make you have until 8th January 2019 as that is when public…
It has been a while, but if you recall in the previous (and first) blog in this series, we gave the potted history of the main TTC benchmarks that can used to assess an untested chemical. For any exuding a structural suspicion of genotoxicity, the…
A wide spectrum of risk assessors are enamoured of the TTC, which essentially uses a knowledge of the toxicological properties of the universe of tested chemicals to make conservative predictions of the likely toxicity of untested materials. It gives them pragmatic respite from the onward…