Current regulatory guidelines for assessing the risk associated with chemical mixtures generally assume that substances with diverse mechanisms of action will act independently (i.e. not additively), even if they share common overt effects. However, a recent study forms part of mounting evidence that this may not be the case for certain types of chemicals. US scientists looked at reproductive tract development in male rat offspring whose mothers were exposed during pregnancy (by stomach tube) to mixtures of seven antiandrogenic substances with diverse structures and mechanisms of toxicity. They found that the chemicals acted in a cumulative manner (i.e. not independently), and that models involving dose addition or toxic equivalency best described the observed dose-response (Rider C.V. et al., International Journal of Andrology 2008, 31, 249). {175221}

The above item is taken from the April 2008 issue of Toxicology and Regulatory News which is sent automatically to members of bibra (click here for more details).

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