A guidance statement from the Committee on Carcinogenicity provides an overview of the various methods that may be used to derive PODs for estimating the relative potency of genotoxic carcinogens. These include the COC’s preferred approach (where possible) of the benchmark dose (BMD), the no- or lowest-observed-adverse-effect level (NOAEL or LOAEL), and potency estimates such as the T25 or TD50, which define the doses eliciting a 25 or 50% increase in the incidence of animals with tumours at a specific site(s), above the background level, within the standard lifespan of that species. The COC recognises that, where chemical-specific data are lacking, the threshold of toxicological concern (TTC) approach provides a pragmatic means of assessing whether or not a particular level of exposure is too high.

Committee on Carcinogenicity of Chemicals in Food, Consumer Products and the Environment. Defining a point of departure and potency estimates in carcinogenic dose response. COC/G 05 – Version 1.0. July 2014. https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/359324/Defining_a_point_of_departure_and_potency_estimates_in_carcinogenic_dose_response.pdf

 

The above items were taken from the November 2014 issue of Toxicology and Regulatory News which is sent automatically to members of bibra (click here)

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