The COM has produced a draft paper (MUT/2013/02) on photogenotoxicity testing. Factors such as the molar extinction coefficient (MEC; the efficiency with which a molecule can absorb a photon of light of specific energy, as defined by wavelength), eye and skin photosafety and the relationship between chemical photoreactivity and photogenotoxicity were considered. The Committee proposes that:

  • Photogenotoxicity testing should not be undertaken as part of a photosafety assessment
  • The prediction of photocarcinogenic potential should involve in vitro and in vivo phototoxicity tests for chemicals with an MEC >1000 Lmol-1 cm-1
  • Photogenotoxicity testing could be used on a case-by-case basis for the assessment of the mode of action for phototoxic chemicals

COM members considered a draft paper (MUT/2013/03) presenting an update on method developments in the Pig-a gene mutation assay, along with the outcomes of validation trials and its general progress as a potential new tool in the genotoxicity battery of test assays.

Swimming pool disinfection by-products (DBPs) and genotoxicity was the subject of a recent draft discussion paper (MUT/2013/04). Available exposure and relevant genotoxicity data are presented.

UK Committee on Mutagenicity of Chemicals in Food, Consumer Products and the Environment.
Draft Summary Statement on photogenotoxicity testing, MUT/2013/02, February 2013.
An update on the development and validation of the Pig-a gene mutation assay, MUT/2013/03, February 2013.
Draft discussion paper on swimming pool disinfection by-products and genotoxicity assessment. MUT/2013/04, February 2013.

http://www.iacom.org.uk/papers/documents/MUT2013-02DraftStatementonPhotogenotoxicity.pdf

http://www.iacom.org.uk/papers/documents/MUT2013-03-Pig-Ageneassay.pdf

http://www.iacom.org.uk/papers/documents/MUT2013-04Swimmingpooldisinfectionby-productsfinal.pdf

 

The above item was taken from the March 2013 issue of Toxicology and Regulatory News which is sent automatically to members of bibra (click here for more details).

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