- Photogenotoxicity testing should not be undertaken as part of a photosafety assessment
- The prediction of photocarcinogenic potential should involve in vitro and in vivo phototoxicity tests for chemicals with an MEC >1000 Lmol-1 cm-1
- Photogenotoxicity testing could be used on a case-by-case basis for the assessment of the mode of action for phototoxic chemicals
COM members considered a draft paper (MUT/2013/03) presenting an update on method developments in the Pig-a gene mutation assay, along with the outcomes of validation trials and its general progress as a potential new tool in the genotoxicity battery of test assays.
Swimming pool disinfection by-products (DBPs) and genotoxicity was the subject of a recent draft discussion paper (MUT/2013/04). Available exposure and relevant genotoxicity data are presented.
UK Committee on Mutagenicity of Chemicals in Food, Consumer Products and the Environment.
Draft Summary Statement on photogenotoxicity testing, MUT/2013/02, February 2013.
An update on the development and validation of the Pig-a gene mutation assay, MUT/2013/03, February 2013.
Draft discussion paper on swimming pool disinfection by-products and genotoxicity assessment. MUT/2013/04, February 2013.
http://www.iacom.org.uk/papers/documents/MUT2013-02DraftStatementonPhotogenotoxicity.pdf
http://www.iacom.org.uk/papers/documents/MUT2013-03-Pig-Ageneassay.pdf
http://www.iacom.org.uk/papers/documents/MUT2013-04Swimmingpooldisinfectionby-productsfinal.pdf
The above item was taken from the March 2013 issue of Toxicology and Regulatory News which is sent automatically to members of bibra (click here for more details).
News Home Guest Write For Us? Contact Us