The Dutch Expert Committee on Occupational Safety has proposed draft “health-based calculated occupational cancer risk values” (HBC-OCRVs) for the presumed (Carc. 1B) human carcinogens 1,2-dichloroethane and 4,4’-methylene bis(2‑chloroaniline), both of which are thought to act by a “stochastic” (i.e. non-threshold genotoxic) mode of action. The HBC-OCRV figures are defined as occupational (40-year) exposures associated with excess cancer mortality levels of 4 per 1,000 and 4 per 100,000. For 1,2-dichloroethane, respective HBC-OCRVs of 12.6 and 0.126 mg/m3 were calculated, while for 4,4’-methylene bis(2-chloroaniline) the equivalent figures were 2.6 and 0.026 mg/m3.

Health Council of the Netherlands (2018). Dutch Expert Committee on Occupational Safety. Reports dated 28 June.


The above items were taken from the August 2018 issue of Toxicology and Regulatory News which is sent automatically to members of bibra.

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