The Dutch Expert Committee on Occupational Safety has proposed draft “health-based calculated occupational cancer risk values” (HBC-OCRVs) for the presumed (Carc. 1B) human carcinogens 1,2-dichloroethane and 4,4’-methylene bis(2‑chloroaniline), both of which are thought to act by a “stochastic” (i.e. non-threshold genotoxic) mode of action. The HBC-OCRV figures are defined as occupational (40-year) exposures associated with excess cancer mortality levels of 4 per 1,000 and 4 per 100,000. For 1,2-dichloroethane, respective HBC-OCRVs of 12.6 and 0.126 mg/m3 were calculated, while for 4,4’-methylene bis(2-chloroaniline) the equivalent figures were 2.6 and 0.026 mg/m3.

Health Council of the Netherlands (2018). Dutch Expert Committee on Occupational Safety. Reports dated 28 June.

1,2-Dichloroethane. Health-based recommendation on occupational exposure limits. Draft. https://www.gezondheidsraad.nl/sites/default/files/dce_conceptadvies_ocr.pdf

4,4’-Methylene bis (2-chloroaniline). Health-based calculated occupational cancer risk values. Draft. https://www.gezondheidsraad.nl/sites/default/files/ocr_moca_2018.pdf

 

The above items were taken from the August 2018 issue of Toxicology and Regulatory News which is sent automatically to members of bibra.

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