The Dutch Expert Committee on Occupational Safety has finalised its advisory report for 1,2-dichloroethane. The chemical was classified as a stochastic (i.e. non-threshold) genotoxic carcinogen, therefore no threshold could be derived below which there was no risk of cancer. Based on a chronic inhalation study in mice in which various tumour types were identified, DECOS estimated the atmospheric concentration of 1,2-dichloroethane corresponding to an excess cancer risk of 4 per 100,000 (the target risk level) to be 126 µg/m3, based on 40 years of occupational exposure.

Health Council of the Netherlands (2019). Dutch Expert Committee on Occupational Safety. 1,2-Dichloroethane. No. 2019/16, The Hague, August 27, 2019.


The above items were taken from the October 2019 issue of Toxicology and Regulatory News which is sent automatically to members of bibra.

News Home Guest Write For Us? Contact Us