1,6-Hexanediol diacrylate (HDDA) caused severe, delayed, skin irritation in humans and was reported to irritate the rabbit eye. It has given evidence of skin sensitizing potential in man and cross-reaction to other acrylates may occur. A moderate sensitizing potential has been demonstrated in guinea-pigs. HDDA demonstrated a low acute oral toxicity in rats and a low acute dermal toxicity in rabbits. Unpublished skin studies found no evidence of reproductive effects when pregnant rats were treated or of carcinogenicity in male mice. A brief citation notes that HDDA was mutagenic in mammalian cells in culture. No evidence of mutagenicity has been seen in Ames bacterial tests.

Date of Publication: 1990

Number of Pages: 4

CAS Number*: 13048-33-4

Format: PDF available for immediate download

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