2-Bromo-2-nitro-1,3-propanediol (BNP) was a skin and eye irritant in man and laboratory animals. It has demonstrated skin sensitization potential in humans and guinea-pigs. The acute oral toxicity to rats, mice and dogs was moderate with toxic effects including gastro-intestinal damage. In rats, single exposure was moderately toxic by the dermal route. Effects seen on repeated oral administration to rats included changes to the gastro-intestinal tract, kidneys, gastric lymph nodes and salivary glands. A decrease in maternal weight gain has been reported in pregnant rats and rabbits fed BNP but there were no effects on the foetuses apart from delayed skeletal development in rats. A limited report noted no evidence of carcinogenicity in rats treated orally or in mice treated dermally. BNP gave no indication of mutagenicity in mice or in Ames bacterial tests.

Date of Publication: 1995

Number of Pages: 9

CAS Number*: 52-51-7

Format: PDF available for immediate download

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