2-Phenoxyethanol was an irritant to the skin and eyes of laboratory animals and a few skin sensitization reactions have been reported in man. It was of low acute toxicity by the dermal and oral routes in laboratory animals. Repeated oral administration to rats and mice produced damage to the liver, kidney, testis and thyroid gland. In rabbits, damage to the liver, kidney and blood was caused by dermal exposure. Repeated skin applications to pregnant rabbits produced no embryotoxic effect. Brief reports indicate that there was no evidence of genotoxicity in mammalian cells in culture or in bacterial tests (including an Ames assay). Chromosomal damage was evidently not observed in mice exposed to 2-phenoxyethanol.

Date of Publication: 1988

Number of Pages: 5

CAS Number*: 122-99-6

Format: PDF available for immediate download

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